D7S486 loss, del(7q31)
Loss of a whole chromosome 7(-7) or a deletion of the long arm of chromosome 7, del(7q), occurs frequently in many types of primary cancers including cases of acute myelogenous leukemia (AML). Loss of the D7S486 locus is detected in ~5% of adults with de novo myelodysplastic syndrome (MDS) and in ~50% of children with de novo MDS. Additionally, loss of the D7S486 locus is observed in 5% of de novo acute myeloid leukemia (AML) patients and in 30 – 40% of therapy related MDS (t-MDS)/AML (t-AML) patients.
Deletion of the D7S486 locus or monosomy of chromosome 7 is associated with a poor prognosis in adults and children diagnosed with MDS and/or AML.
References:
- Heim, S., Mitelman, F., (2009) (Ed). Cancer Cytogenetics, (3rd Edition). Wiley-Blackwell, New Jersey. P. 141-178.
- Shali, W., et al., (2006) Cancer Genet Cytogenet. 168(2): p. 133-145.
- Haase, D. (2008) Ann Hematol. 87(7):p.515-26.
