Gain of chromosome 8, 8p11
The gain of chromosome 8 is found in 15-20% of myelodysplastic syndromes (MDS). The progression of MDS to AML occurs in about half of these cases, while mean survival is about 1.5 to 2 years.
Leukemias +8 appear to be a heterogeneous group with different clinical and cytological presentations, and different expression profiles as well. Genes involved in this alteration are not known. Polyploidy of chromosome 8 is probably a secondary event, even in cases where no known primary abnormality is associated. Patients with constitutional chromosome 8 trisomy have an increased risk of developing leukemia.
- Schoch C, et al. Genes Chromosomes Cancer. (2006, 45(12):1164-8.