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Gain of chromosome 8, 8p11

The gain of chromosome 8 is found in 15-20% of myelodysplastic syndromes (MDS). The progression of MDS to AML occurs in about half of these cases, while mean survival is about 1.5 to 2 years.

Leukemias +8 appear to be a heterogeneous group with different clinical and cytological presentations, and different expression profiles as well. Genes involved in this alteration are not known. Polyploidy of chromosome 8 is probably a secondary event, even in cases where no known primary abnormality is associated. Patients with constitutional chromosome 8 trisomy have an increased risk of developing leukemia.

References:

  • Schoch C, et al. Genes Chromosomes Cancer. (2006, 45(12):1164-8.

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