ZNF217 gene amplification (20q13.2)
The ZNF217 gene is a suggested oncogene candidate for its role in neoplastic transformation. ZNF217 is located in 20q13.2, frequently amplified region in a wide variety of tumors. ZNF217 amplification in breast cancer is associated with tumor aggressiveness and poor clinical prognosis. Some studies have identified ZNF217 gain an important tumorigenesis prognostic factor in laryngeal cancer.