October 23, 2015

Deletion of 5q, del(5q) Partial or complete deletion of the long arm of chromosome 5 [del(5q)], with or without additional karyotypic abnormalities, is present in 10-15% of myelodysplastic syndromes (MDS). Anemia in these MDS responds less often to erythroblastic stimulating agents. However, immunomodulatory, anti-cytokine, and anti-angiogenic agent Lenalidomide (CC5013) leads to red blood cells transfusion […]

Deletions in 1p and amplifications in 1q Chromosome 1 aberrations are the most common structural aberrations in MM and mostly involve deletions in 1p and amplifications in 1q. The deletions of 1p are mainly interstitial deletions and are associated with a poor prognosis. Chromosome 1 aberrations involving the q arm are particularly complex and tend