LAROTRECTINIB IN TRK FUSION–POSITIVE SOLID TUMORS

TRK fusion–positive solid tumors represent a unique molecular subgroup of tumors that are susceptible to larotrectinib therapy.

This pooled analysis of three phase I/II trials was designed to evaluate the benefit of larotrectinib in patients with TRK fusion–positive solid tumors. The objective response rate was 79%, with a complete response rate of 16%. The safety profile was manageable.

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