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This phase II trial was designed to evaluate the benefit of daratumumab monotherapy for patients with intermediate-risk or high-risk smoldering multiple myeloma. The 24-month progression-free survival rate ranged from 75.3% to 89.9%, depending on dosing intensity.

Phase III trials to evaluate daratumumab monotherapy in smoldering multiple myeloma are warranted.

https://www.nature.com/articles/s41375-020-0718-z#citeas

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