ROS1 rearrangements, t(6q22) ROS1 gene encodes a receptor tyrosine kinase which belongs to the insulin receptor family, with downstream signaling via the MAPK pathway through phosphorylation of RAS. Chromosomal rearrangements involving ROS1 gene (6q22) have recently been identified and described in 1–2% of patients with lung cancer. In lung cancer, ROS1 fusion partners include FIG, […]
Loss of P53 , del(17p13) TP53 (17p13.1) is a tumor suppressor gene that regulates cell division while maintaining the growth and division of cells at optimal levels and avoiding rapid or uncontrolled cell growth. Loss of region 17p13.1 (TP53) is a recurrent deletion occuring in a number of leukemias, such as CLL and multiple myeloma
TLX3 rearrangements, t(5;14) Most chromosomal translocations observed in T-cell acute lymphoblastic leukemia (T-ALL) often produce transcriptional activation of transcription factor oncogenes. Ectopic expression of the TLX3 (also known as HOX11L2) gene, located in 5q35, has been shown to be associated with a cryptic t(5;14)(q35;q32) specific translocation for a subtype of T-ALL. t(5;14)(q35;q32) is found in
SIL-TAL1 , del(1p32) TAL1 gene (T-cell acute leukemia gene 1) is normally expressed in pluripotent hematopoietic cells, mast cells, megakaryocytes and erythroid cell maturation, but never in lymphoid cells. About 30% of T-ALL carry aberrations in the TAL1 gene. Most of the time, about 25% of cases, this aberration consists of a 90 kb deletion
