ctDNA to Guide Panitumumab Rechallenge in Metastatic Colorectal Cancer

Monoclonal antibodies against epidermal growth factor receptor (EGFR) are approved for the treatment of metastatic RAS-like colorectal cancer (WT), but the emergence of resistance mutations restricts their efficacy. Previous studies demonstrated that mutant alleles of RAS, BRAF and EGFR, which appear in circulating tumor DNA (ctDNA) during blockade, decrease upon withdrawal of therapy. CHRONOS hypothesized that …

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