MYD88
MYD88 L265P mutation MYD88 L265P mutation appears to be the most frequent mutation described to date in WM (91% of cases). MYD88 L265P mutation may be considered as the first genetic hit in Waldeström Macroglobulinemia that promotes NF-κB and JAK-STAT3 signaling and subsequently initiates alteration of major pathways, such as apoptotic pathways. The diagnostic discrimination of […]
