August 10, 2015

[vc_row][vc_column][vc_column_text] del(6q21) Deletion of the long arm of chromosome 6, is detected more often in lymphoproliferatives syndromes in other hematological malignancies. It can be observed in acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), prolymphocytic leukemia and non-Hodgkin lymphomas (NHL ) (15% of cases, sometimes associated with t(14;18) (q32; q21)). del(6q21) is the most common […]

PAX5/IGH, t(9:14)(p13; q32) t(9:14)(p13; q32) is an atypical recurrent chromosomal abnormality that is detected exclusively in B-cell lymphoproliferative disorders. PAX5 belongs to a family of transcription factors involved in processes of development and its expression is required during the early stages of B cell development. The translocation affects the gene PAX5, which abnormally locates on