1;19 – TCF3-PBX1

TCF3-PBX1 fusion gene, t(1;19)

t(1;19)(q23;p13) translocation event between the TCF3 locus (19p13.3) and PBX1 locus (1q23) which produces the chimeric gene TCF3-PBX1, is present in most type L1 and type L2 ALLs and exceptionally in ALL- L3.

The translocation occurs in approximately 5% of childhood ALL and while this chromosomal anomaly usually was associated with poor prognosis, nowadays associates with good prognosis with modern intensive protocols.