IGH/FGFR3 translocation, t(4;14)(p16;q32)
The t(4;14) translocation is associated with upregulation of the fibroblast growth factor receptor 3 (FGFR3) and the myeloma SET domain protein. This reciprocal translocation is a common alteration in multiple myeloma (MM) not often detected by classic cytogenetics, because of the telomeric location of the regions involved. Patients with t(4;14) demonstrate an overall poor prognosis that is only partially mitigated by the use of the novel agents bortezomib and lenalidomide.
References
- Kalff A, Spencer A. (2012) Blood Cancer Journal. 2(9):e89-.
- Fonseca R, et al. (2009) Leukemia. 23(12):2210-21.
- Anderson KC, et al. (2009) J Natl Compr Canc Netw. 7(9)908-42.
- Avet-Loiseau H, et al. (2007) Blood. 109(8):3489-95.
