cMYC amplification (8q24)
The c-MYC oncogene is located in 8q24 and in its locus (8q24.2-q24.3) amplifications can be found frequently in various types of human tumors (c-MYC amplifications have been described in breast, lung, ovary, cervical and prostate cancer). Two of the most significant genetic alterations detected in prostate cancer include 8q24 gain and loss 8p21-22 heterozygous. It is believed that genes located in 8p may be involved in the tumor early stages.
Analysis of c-MYC locus, along with LPL and CEP8, lets establish the prognosis in prostate cancer. 8q24 gain is a common event in prostate cancer and is often accompanied by loss of 8p21-22. 8q24 amplification is associated with MYC expression and prostate cancer progression and is an independent predictor of recurrence after radical prostatectomy. Another of the most frequent abnormalities found in prostate cancer is the gain of chromosome 8.
References
- Fromont, G et al. (2013) Hum Pathol. 44(8):1617-23.
- Koh CM, (2010) Genes Cancer. 1(6):617-28
- Hawkswoth D, et al. (2010) Prostate Cancer Prostatic Dis.13(4):311-5
- Ahmadiyeh N, et al. (2010) Proc Natl Acad Sci USA. 107(21):9742-6
- Gallucci M, et al. (2009) Urol Oncol. 27(5):502-8.
- Gurel B, et al. (2008) Mod Pathol. 21(9):1156-67
