CMYC amplification, (8q24)
Nuclear oncoprotein C-myc is involved in the regulation of cell proliferation, cell differentiation and apoptosis. Amplification and overexpression has been associated with numerous cancers, including esophageal tumors. Loss of FHIT and/or gain of MYC are related to an adverse prognosis in resected Esophageal Squamous Cell Carcinoma, and their use in a risk classification warrants to select the optimal treatment strategy in resected patients.
References:
- Geppert CI, et al. (2014) Br. J. of Cancer, 110, 2985–2995.
- Miyawaki, Y et al. (2012) Cancer Sci. 103(8): 1558–156
- Martín-Ezquerra G, et al. (2010) Br. Assoc. Dermatol. 163: 1028–1035.
- Watson, JV et al. (1987) Oncol. 28: 137–150.
