PAX5/IGH, t(9:14)(p13; q32)
t(9:14)(p13; q32) is an atypical recurrent chromosomal abnormality that is detected exclusively in B-cell lymphoproliferative disorders. PAX5 belongs to a family of transcription factors involved in processes of development and its expression is required during the early stages of B cell development. The translocation affects the gene PAX5, which abnormally locates on chromosomal region 14q32. Unlike other rearrangements in the IGH gene (14q32), this condition does not produce a fusion gene, but forces PAX5 expression, contributing to the pathogenesis of such lymphomas.
