Next-generation deep sequencing was used to determine the mutational status of hotspot regions in 340 adults and children with B-cell precursor ALL. The frequency of adult vs child mutations was significantly higher (20.2% vs 7.6%). The most commonly mutated genes were TP53, JAK2, CRLF2, PAX5, LEF1, and IL7R, respectively. Significantly lower overall survival and event-free survival rates and significantly higher relapse rates were associated with TP53 mutations in children. In adults, TP53 mutations were associated with significantly lower overall survival and significantly higher relapse rates. JAK2 mutations were associated with significantly higher relapse rates and significantly lower event-free survival in adults.
These findings suggest that TP53 and JAK2 are significant predictors of poor prognosis for patients with B-cell ALL.
https://www.ncbi.nlm.nih.gov/pubmed/28557976
