IGH-BCL2, t(14;18) (q32;q21)
The t(14;18) chromosomal translocation that results in the juxtaposition of the BCL2 proto-oncogene with the heavy chain JH locus. It a common cytogenetic abnormality in human lymphoma and is observed in about 85% of follicular lymphoma and up to one-third of diffuse lymphomas. Two breakpoint region clusters (brc) have been identified: a major breakpoint region (mbr) within the 3’ untranslated region of the BCL2 proto-oncogene accounting for approximately 60% of the cases and a minor cluster region (mcr) 30 kb 3’ of BCL2 accounting for approximately 25% of the breakpoints.
