PLASMA HER2 (ERBB2) COPY NUMBER PREDICTS RESPONSE TO HER2-TARGETED THERAPY IN METASTATIC COLORECTAL CANCER.
ERBB2 (HER2) amplification is an emerging biomarker in colon cancer, conferring sensitivity to combination anti-HER2 therapy. Measurement of HER2 copy number is typically performed using surgical specimens, but cell-free circulating tumor DNA (ctDNA) analysis may be a noninvasive alternative. We determined the sensitivity of plasma copy number (pCN) for detecting ERBB2 amplifications and whether pCN […]
