Implications of BRAF V600E Mutations in Pediatric Low-Grade Gliomas.
The role of BRAF V600E mutations in pediatric low-grade glioma (PLGG) is debated. Lassaletta and colleagues evaluated two cohorts of PLGG for BRAF V600E mutations and the association with clinical outcome. Although PLGG, overall, has favorable disease control with surgery and adjuvant therapy, patients with BRAF mutations had significantly worse disease control and progression-free survival. […]
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