Association of MYCN copy number with clinical features, tumor biology, and outcomes in neuroblastoma.
High-level MYCN amplification (MNA) is associated with poor outcome and unfavorable clinical and biological features in patients with neuroblastoma. Actual knowledge regarding these associations in patients with low-level MYCN copy number increases is less known. In a retrospective study, the authors classified patients has having tumors with MYCN wild-type tumors, MYCN gain (2-4-fold increase in MYCN signal compared with the reference probe), or MNA (>4-fold increase). Tests of trend were used […]
