Mutations in KRAS Codon 12 Are Associated With Worse Overall Survival in Colorectal Cancer
In a retrospective study, researchers evaluated the impact of specific KRAS mutations among 392 patients with advanced and recurrent colorectal cancer. They detected KRAS mutation in 42.9% of tumors and found that KRAS mutation was predictive of overall survival (HR, 1.54; P = .005). Specifically, worse overall survival was associated with KRAS codon 12 mutations […]
