January 25, 2016

Researchers assessed the characteristics, molecular profiles, and clinical outcomes of patients with non–small cell lung cancer who were screened over the course of 1 year to determine how feasible molecular profiling is on a routine basis and what effect the screening has on outcomes. They measured the frequency of molecular alterations in six genes routinely […]

Deletions of chromosome 10q23, including the PTEN (phosphatase and tensin homolog) locus, are known to occur in breast cancer, but systematic analyses of its clinical relevance are lacking. Recent study analyzed a tissue microarray (TMA) with 2,197 breast cancers by fluorescence in-situ hybridization (FISH) using a PTEN-specific probe. PTEN deletions were detected in 19 % of no