While the negative prognostic role of BRAF V600E mutation in metastatic colorectal cancer (mCRC) is well-established, the impact of BRAF codons 594 and 596 mutations, occurring in <1% of CRCs, is completely unknown. Recent studies at three Italian Institutions suggest that patients with BRAF codons 594 or 596 mutated tumors had markedly longer overall survival […]
CCND1-IGH, t(11;14)(q13;q32) Mantle cell lymphoma is a subtype of non-Hodgkin lymphoma characterized by poor prognosis. Cytogenetically t(11;14) is associated with 75% of mantle cells lymphomas. The translocation breakpoints are scattered within the 120 kb BCL1 region adjacent to CCND1. The translocation leads to overexpression of cyclin D1 due to juxtaposition of the Ig heavy chain
IGH-BCL2, t(14;18) (q32;q21) The t(14;18) chromosomal translocation that results in the juxtaposition of the BCL2 proto-oncogene with the heavy chain JH locus. It a common cytogenetic abnormality in human lymphoma and is observed in about 85% of follicular lymphoma and up to one-third of diffuse lymphomas. Two breakpoint region clusters (brc) have been identified: a
