11;14, CCND1-IGH

CCND1-IGH, t(11;14)(q13;q32)

Mantle cell lymphoma is a subtype of non-Hodgkin lymphoma characterized by poor prognosis. Cytogenetically t(11;14) is associated with 75% of mantle cells lymphomas. The translocation breakpoints are scattered within the 120 kb BCL1 region adjacent to CCND1. The translocation leads to overexpression of cyclin D1 due to juxtaposition of the Ig heavy chain gene enhancer on 14q32 to the cyclin D1 gene on 11q13.