RISK ASSESSMENT FOR DISTANT METASTASIS IN DIFFERENTIATED THYROID CANCER USING MOLECULAR PROFILING

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The authors of this case–control study compared the ThyroSeq genetic profiles of 62 patients with differentiated thyroid cancer with distant metastasis to a propensity-matched cohort without metastatic disease after over 5 years of follow-up.

A TERT, TP53, or PIK3CA mutation was found in two-thirds of patients in the cohort with distant metastatic disease. The high-risk molecular profile, defined as the presence of an early mutation and “late-hit” TERT, TP53, PIK3CA, or AKT1, was strongly associated with distant metastases on the propensity-matched analysis.

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