News

1p32, SIL/TAL1

SIL-TAL1 , del(1p32) TAL1 gene (T-cell acute leukemia gene 1) is normally expressed in pluripotent hematopoietic cells, mast cells, megakaryocytes and erythroid cell maturation, but never in lymphoid cells. About 30% of T-ALL carry aberrations in the TAL1 gene. Most of the time, about 25% of cases, this aberration consists of a 90 kb deletion […]

1p32, SIL/TAL1 Read More »

BRAF as a predictive marker of benefit from anti-EGFR therapies in metastatic colorectal cancer

Metastatic colorectal cancer (mCRC) having the V600E BRAF mutation is associated with poor prognosis. However, currently it is not proven that the presence of this mutation is an indicator of benefit to treatment with anti-EGFR (epidermal growth factor receptor) monoclonal antibodies A recent meta-analysis and systematic review of randomized controlled trials published until July 2014

BRAF as a predictive marker of benefit from anti-EGFR therapies in metastatic colorectal cancer Read More »