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Sarcomas are rare, numerous in type, and often difficult to definitively classify. Work in the last 2 decades has revealed that a significant subset of sarcomas are associated with specific chromosomal translocations producing chimeric (fusion) genes that play a role in the sarcomas’ biology and are helpful in their differential diagnosis.

12q13, CHOP (DDIT3) 13q14, FOXO1 (FKHR) 13q14, FOXO1/FKHR 16p11, FUS 22q13, PDGFB 22q12, EWS 12q14, MDM2 18q11, SS18 (SYT)