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Neuroblastoma is the most common extracranial solid tumor in childhood that exhibits a heterogeneous clinical behavior ranging from low-risk tumors with ability to differentiate spontaneously and regression, to high-risk tumors causing the greatest number of cancer-related deaths in children. The different biological behavior of neuroblastoma tumors is due to the large number of recurrent chromosomal imbalances present at the time of diagnosis. These chromosomal imbalances include whole chromosomes hyperdiploidy, partial loss of 1p, 3p, 4p, 11q, 14q, partial increase in 1q, 7q, 17q and amplification of NMYC.

2p24, NMYC