Oops! It appears that you have disabled your Javascript. In order for you to see this page as it is meant to appear, we ask that you please re-enable your Javascript!

Mantle cell lymphoma is a rare form of malignant non-Hodgkin lymphoma affecting B lymphocytes in the lymph nodes in a region called the “mantle zone”. It accounts for 2-10% of lymphomas. Mantle cell lymphoma affects middle-aged adults, especially around 65 years. At diagnosis, most patients present with a disseminated form of the disease. Mantle cell lymphoma is caused by a chromosomal translocation t(11;14) (q13;q32). Diagnosis is based on lymph node biopsy revealing the presence of tumor cells. Phenotypic immunohistochemical analysis as well as evidence of abnormal expression of cyclin D1 (or the translocation t(11;14) by FISH or conventional cytogenetics) is necessary to confirm the diagnosis.

11;14, CCND1-IGH 3q27, BCL6