Burkitt’s lymphoma is an aggressive B-cell form of Non-Hodgkin lymphoma that occurs most often in children and young adults. There are three main types of Burkitt’s lymphoma: sporadic (occurs throughout most of the world), endemic (found mostly in Africa and is often associated with the Epstein-Barr virus (EBV), and immunodeficiency-related disease (diagnosed most often in people infected with HIV/AIDS).
Burkitt’s lymphoma characteristic chromosomal translocation involves MYC gene locus, located in chromosome 8. The most common variant is t(8;14)(q24;q32), while other variations include other chromosome translocations: t(2;8)(p12;q24) and t(8;22)(q24;q11). A much rarer three chromosome translocation, t (8; 14; 18), has been identified.