IMPLICATIONS OF TP53 ALLELIC STATE FOR GENOME STABILITY, CLINICAL PRESENTATION AND OUTCOMES IN MYELODYSPLASTIC SYNDROMES
Tumor protein p53 (TP53) is the most frequently mutated gene in cancer. In patients with myelodysplastic síndromes (MDS), TP53 mutations are associated with high-risk disease, rapid transformation to acute myeloid leukemia (AML)5, resistance to conventional therapies and dismal outcomes. Consistent with the tumor-suppressive role of TP53, patients harbor both mono- and biallelic mutations. However, the […]
