ASSOCIATION OF SPAG5 AND TREATMENT RESPONSE IN PATIENTS WITH ER-POSITIVE BREAST CANCER

Sperm-associated antigen 5 (SPAG5) represents a novel oncogene in estrogen receptor (ER)–positive luminal-B breast cancer. The authors of this study evaluated the association of SPAG5 gene and protein expression and treatment response in 12,270 patients with ER-positive breast cancer. Overexpression was associated with higher odds of a pathologic complete response. Furthermore, among women with SPAG …

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