October 13, 2015

Pancreatobiliary cancer is detected by fluorescence in situ hybridization (FISH) of pancreatobiliary brush samples with UroVysion probes, originally designed to detect bladder cancer. A group of researchers (Barr Fritcher, E.G. 2015) tested a set of FISH probes on tumor tissues (cholangiocarcinoma or pancreatic carcinoma) and non-tumor tissues from 29 patients. The combination of FISH probes […]

A retrospective-prospective analysis of a phase 3 randomized trial (Peeters, M. et al. 2015) examined the influence of extended RAS mutation evaluation on second-line efficacy of fluorouracil, leucovorin, and irinotecan (FOLFIRI) plus panitumumab or FOLFIRI alone in 1186 patients with metastatic colorectal cancer (mCRC). RAS mutations beyond KRAS exon 2 (KRAS exons 3, 4, NRAS